Endocannabinoidal System


Endocannabinoidal System

The Endocannabinoid System is a system in the body that aids the body in maintaining homeostasis. The endocannabinoid system promotes well-being and balance in the whole body.

The human body naturally produces its own cannabinoids, such as 2-Arachidonoyl (2-AG) and Anandamide (AEA), and when they are produced within the body they are called endocannabinoids. When people experience a runner’s high (the feelings of euphoria after an intense workout) that is actually caused by their own bodies endocannabinoids.

The endocannabinoid system is the network of receptors that interact with cannabinoids; CB1 receptors are found primarily in the brain, and CB2 is located throughout the immune system. The human body naturally produces cannabinoids and this is why the body has endocannabinoid receptors.

CB1 receptors are mainly found in the brain and are responsible for dealing with:

  • Pain
  • Movement coordination
  • Cognitive abilities(thinking, memory)
  • Appetite
  • Emotions

CB1 is actually the most numerous receptor expressed in the human brain.

CB2 receptors are more commonly found in the immune system and have an effect on pain and inflammation. The CB2 receptor is primarily localized in the peripheral aspect of the body (i.e.

  • GI tract
  • Tonsils
  • Spleen
  • Immune cells

Both receptors serve major roles in homeostasis and biofeedback mechanisms.

When CBD enters the body, it stimulates the body to create more of its own endocannabinoids and helps to regulate the endocannabinoid system.